![]() One of the key integrator of these complex mechanisms is the canonical WNT/β-catenin pathway 13, 14. In many ASD findings, the WNT/β-catenin pathway is increased 7, 9, 10, 11.Ĭircadian clocks have a main role in some tissues by driving circadian expression of genes involved in physiologic and metabolic functions 12. Several genetic mutations observed in ASD are linked with the dysregulation of the WNT/β-catenin pathway through interactions between chromodomain helicase DNA binding protein 8 (CHD8) and CTNNB1 (β-catenin) 8. One of the main pathways implicated in developmental cognitive disorders is the canonical WNT/β-catenin pathway 7. Recent studies have shown that the deregulation of the core neurodevelopmental signaling is correlated with ASD clinical presentation. Biologic rhythms are complex systems interacting with the environment and controlling several physiological pathways, including brain development 5 and behavioral processes 6. Brain structures and functions development are considered as dynamic processes, dependent on genetic and social/physical environmental cues, involving homeostasis processes at each time, and maturation of new functions in time. Early diagnosis is major issue for better prognosis and therapeutic care 2, 3.ĪSD is frequently associated with sleep disorders 4. Social interaction impairment, repetitive and restrictive behaviors or stereotypic patterns of behaviors characterize the different symptoms of ASD 1. ASD is diagnosed within the first 3 years of life. Nevertheless, the main causes of ASD remain unclear. ASD is characterized by numerous and complex etiologies, including inflammation, metabolic, environmental or genetic determinants. ASD includes Asperger, autism and pervasive developmental disorder-not otherwise specified (PDD-NOS). Intellectual abilities and their clinical presentations are extremely heterogeneous in autism spectrum disorder (ASD). This review focuses on the interest of circadian rhythms dysregulation in metabolic reprogramming in ASD through the aberrant upregulation of the canonical WNT/β-catenin pathway. ASD progression is associated with a major metabolic reprogramming, initiated by aberrant WNT/β-catenin pathway, the aerobic glycolysis. In ASD, the increase of the canonical WNT/β-catenin pathway is enhancing by the dysregulation of circadian rhythms. Circadian clocks have a main role in some tissues by driving circadian expression of genes involved in physiologic and metabolic functions. One of the main pathways involved in developmental cognitive disorders is the canonical WNT/β-catenin pathway. Recent findings have shown that the deregulation of the core clock neurodevelopmental signaling is correlated with ASD clinical presentation. Biologic rhythms are complex systems interacting with the environment and controlling several physiological pathways, including brain development and behavioral processes. ![]() ASD is frequently associated with sleep disorders.
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